Ellagitannins {90000308} Record Keys Parent:[ ] Definition:Ellagitannins Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:Anti-inflammatory Notes: [ ]Shared Reference Notes [1.1] - Ellagic tannins, in pomegranate and grape, are not bioavailable but intestinal microbes can convert them into #Urolithins with antioxidant activity and preventive effects for chronic diseases such as cancer, diabetes, and cardiovascular and neurodegenerative diseases [1.2] - microbial-derived #Urolithins have potent anti-inflammatory effects. In human colonic fibroblasts, #Urolithins, but not their ellagitannin precursor, inhibited nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) translocation into the nucleus and consequent activation of downstream inflammatory events. [#Gordonibacter pamelaeae] - The #Urolithins are an important class of bioactive microbial metabolites derived from ellagitannin and #Ellagic acid precursors. - Several bacterial species have been identified that produce their intermediate metabolites including #Gordonibacter urolithinfaciens and G. pamelaeae. [1.3] [#Polyphenols] - #Urolithin A (uroA) is a polyphenol derived from the multi-step metabolism of dietary ellagitannins by the human gut microbiota that can affect host health by stimulating mitophagy.References Notes[ ]
