Sucralose {90000493} Record Keys Parent:[ ] Definition:Sucralose Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Non-nutritive Sweeteners, #Sweeteners] - Notable oral microbiome alterations include changes in relative abundances of six Streptococcus species in the sucralose group , reduced relative abundance of Fusobacterium in the saccharin group, and reduced abundance of Porphyromonas and Prevotella nanceiensis in the aspartame group [1.2] [#Sweeteners] - People may also be exposed to even higher levels when gut bacteria convert sucralose into sucralose-6-acetate. - Sucralose-6-acetate is an intermediate and impurity in the manufacture of sucralose. - sucralose-6-acetate is genotoxic. - Sucralose-6-acetate significantly increased the expression of genes associated with inflammation, oxidative stress, and cancer with greatest expression for the metallothionein 1 G gene (MT1G). - Sucralose-6-acetate and sucralose both impaired intestinal barrier integrity. - Sucralose-6-acetate also inhibited two members of the cytochrome P450 family (CYP1A2 and CYP2C19). [1.3] [#Non-nutritive Sweeteners] - all ArtSw exposures were related to higher BMI, body weight, and waist circumference and, except for sucralose, were associated with increases in these anthropometric measurements over a 25-year period. - Greater risks of developing #Obesity were found across increasing quintiles of total ArtSw, aspartame, sucralose, and diet beverage intakes. [1.4] [#Sweeteners] - The intake of the #Sucrose-sweetened beverage resulted in a significant increase in plasma endotoxin levels while being unchanged after the intake of sucralose-sweetened beverages. - an acute intake of physiologically relevant amounts of #Sucrose but not of sucralose can result in post-prandial endotoxemia.References Notes[ ]
