Retinoic acid {90000331}
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| Definition: | Retinoic acid |
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| Function: | Anti-inflammatory, Anti-bacterial |
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Shared Reference Notes
- [1.1] [#Short Chain Fatty Acid]
- Injection of SCFAs has been shown to enhance retinoic acid (RA) in intentional epithelial cells. - [1.2] [#Citrobacter rodentium] [#Vitamin A]
- Commensal segmented filamentous bacteria protect against C. rodentium infection - Commensal bacteria express enzymes that generate retinoic acid in the intestine - Commensal bacterial-derived retinoic acid promotes epithelial defense in the host - [1.3] [#Systemic lupus erythematosus]
- in Mice > #Resistant Starch (RS), retinoic acid (RA) or all-trans retinoic acid (tRA), and acidic water (AW) had influenced the gut microbiome, leading to an improved lupus development. - [1.4]
- All-trans-retinoic acid treatment reversed pristane-induced leaky gut - [1.5] [#Short Chain Fatty Acid]
- SCFA administration stimulate retinoic acid (RA) production in the intestinal epithelium, a #vitamin #A derivate converted by #Aldehyde dehydrogenases, which is associated with signaling and expansion of peripheral Tregs (pTregs) in the context of a immunosuppressive response - [1.6]
- RA, have been suggested to exhibit beneficial effects in #Alzheimer’s disease by mechanisms that involve inhibiting the formation, elongation, and destabilizing effects of β-#Amyloid fibrils - [#Colorectal cancer] - inflammation induced by gut #Bacteria impacts the metabolism of all-trans retinoic acid (AtRA), resulting in diminished levels of AtRA, this reduction in AtRA levels has been implicated in the advancement of #Ulcerative Colitis (UC) and its associated CRC
References Notes
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