Retinoic acid {90000331} Record Keys Parent:[ ] Definition:Retinoic acid Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:Anti-inflammatory, Anti-bacterial Notes: [ ]Shared Reference Notes [1.1] [#Short Chain Fatty Acid] - Injection of SCFAs has been shown to enhance retinoic acid (RA) in intentional epithelial cells. [1.2] [#Citrobacter rodentium] [#Vitamin A] - Commensal segmented filamentous bacteria protect against C. rodentium infection - Commensal bacteria express enzymes that generate retinoic acid in the intestine - Commensal bacterial-derived retinoic acid promotes epithelial defense in the host [1.3] [#Systemic lupus erythematosus] - in Mice > #Resistant Starch (RS), retinoic acid (RA) or all-trans retinoic acid (tRA), and acidic water (AW) had influenced the gut microbiome, leading to an improved lupus development. [1.4] - All-trans-retinoic acid treatment reversed pristane-induced leaky gut [1.5] [#Short Chain Fatty Acid] - SCFA administration stimulate retinoic acid (RA) production in the intestinal epithelium, a #vitamin #A derivate converted by #Aldehyde dehydrogenases, which is associated with signaling and expansion of peripheral Tregs (pTregs) in the context of a immunosuppressive responseReferences Notes[ ]