ApoE4 allele {51111216} Record Keys Definition:ApoE4 allele Queue:[ ] Details Initialisation date:2021-06-16 Specification: [ ] Meta Information Type:Genetic Host: Human Zone:[ ] Notes: [ ]Shared Reference Notes [1.1] - The ApoE4 allele is the most well-studied genetic risk factor for #Alzheimer’s disease, a condition that is increasing in prevalence and remains without a cure. - Precision nutrition targeting metabolic pathways altered by ApoE4 provides a tool for the potential prevention of disease. [1.2] [#Alzheimer’s disease] [#Short Chain Fatty Acid] - #Amyloid-beta is a necessary factor in AD pathogenesis, its accumulation in and of itself is insufficient for neurodegeneration and cognitive decline. - pathological #Tau accumulation is closely linked with neurodegeneration and cognitive decline in AD and primary tauopathies. - apolipoprotein E (ApoE) isoforms, which strongly influence AD risk and regulate #Tau-mediated neurodegeneration, differentially affect the gut microbiota. - microbially produced short-chain fatty acids (SCFAs) are mediators of the neuroinflammation-neurodegeneration axis. - Supplementation of SCFAs to GF TE4 mice resulted in more reactive glial morphologies and gene expression as well as increased p-#Tau pathology.References Notes[ ]
