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Enhancing bone tissue
- Polyamine improve bone tissue upkeep (1)
Shared Reference Notes
- [1.1] [#Colorectal cancer]
- Polyamines can feed #Cancer cells for growth and any polyamines, regardless of their sources (i.e., dietary, microbial, and tissues) can drive tumorigenesis. - Tumor cells require more polyamines for growth than healthy cells - #Cancer patients have increased polyamine levels in the blood and urine. - Polyamine concentrations appear to be increased in CRC tissues compared to healthy tissues.
- - Amino acids that reach the colon are converted by the microbiome to polyamines or #Indole derivates. - The most common polyamines are #Putrescine, #Spermidine, and #Spermine, which play important roles in cell growth, proliferation, and migration.
- [1.2] [#Polyamines]
- higher tissue polyamine levels have been reported in various diseases like #Dementia due to #Alzheimer’s disease (AD), #Parkinson’s Disease, #Cancer, and mental disorders like #Depression.
- [#Alzheimer’s disease] - Urinary polyamine levels in AD patients were significantly elevated compared to healthy individuals.