Polyamine {60000059}
| Parent: | [ ] |
|---|---|
| Definition: | Polyamine |
| Queue: | [ ] |
| Initialisation date: | 2020-09-22 |
|---|---|
| Specification: | |
| [ ] | |
| Source: | |
| [ ] | |
| Structural Type: | [ ] |
|---|---|
| Functional Type: | [ ] |
| Function: | Enhancing bone tissue |
Notes:
- Polyamine improve bone tissue upkeep (1)
Shared Reference Notes
- [1.1] [#Colorectal cancer]
- Polyamines can feed #Cancer cells for growth and any polyamines, regardless of their sources (i.e., dietary, microbial, and tissues) can drive tumorigenesis. - Tumor cells require more polyamines for growth than healthy cells - #Cancer patients have increased polyamine levels in the blood and urine. - Polyamine concentrations appear to be increased in CRC tissues compared to healthy tissues. - - Amino acids that reach the colon are converted by the microbiome to polyamines or #Indole derivates. - The most common polyamines are #Putrescine, #Spermidine, and #Spermine, which play important roles in cell growth, proliferation, and migration.
- [1.2] [#Polyamines]
- [1.3]
- higher tissue polyamine levels have been reported in various diseases like #Dementia due to #Alzheimer’s disease (AD), #Parkinson’s Disease, #Cancer, and mental disorders like #Depression. - [#Alzheimer’s disease] - Urinary polyamine levels in AD patients were significantly elevated compared to healthy individuals.
References Notes
[ ]