Carboxymethylcellulose {90000239} Record Keys Parent:[ ] Definition:Carboxymethylcellulose Queue:[ ] Details Initialisation date:2022-01-12 Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Crohn’s disease, #Inflamatory bowel disease, #Ulcerative Colitis] [#Western-style diet] - Two commonly used emulsifiers, carboxymethylcellulose and #Polysorbate-80 > induce inflammation and metabolic changes, mediated by gut microbes. [1.2] [#Diabetes Type 1] [#Food emulsifiers] - dietary emulsifier carboxymethylcellulose (CMC) consumption significantly accelerated T1D development. - This is associated with increased serum levels of insulin autoantibody, a marker of T1D early development. - dietary emulsifiers > changed microbiota composition and localization in a way that is associated with the promotion of low-grade intestinal inflammation. - the severity of emulsifier-induced microbiota alterations is partly associated with diabetes status and T1D precocityReferences Notes[ ]
