Coronavirus 2 {50002711} Record Keys Parent:[ ] Definition:Coronavirus 2 Details Initialisation date:[ ] Meta Information Rank:[ ] Domain:[ ] Zone:[ ] Enzyme:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Covid-19] [#Human adenovirus, #Human coronavirus] [#Short Chain Fatty Acid] - Increased abundance of SCFA-producing bacteria appears to offer protection against many common respiratory viruses including #Rhinovirus, #Respiratory syncytial virus, adenovirus, #Influenza and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [1.2] - #High ambient temperature of 36 °C increases host resistance to viral pathogens including #Influenza virus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). - High heat-exposed mice increase basal body temperature over 38 °C to enable more #Bile Acids production in a gut microbiota-dependent manner. - The gut microbiota-derived #Deoxycholic acid (DCA) and its plasma membrane-bound receptor Takeda G-protein-coupled receptor 5 (TGR5) signaling increase host resistance to #Influenza virus infection by suppressing virus replication and neutrophil-dependent tissue damage. - the DCA and its nuclear farnesoid X receptor (FXR) agonist protect Syrian hamsters from lethal SARS-CoV-2 infection. certain #Bile Acids are reduced in the plasma of COVID-19 patients who develop moderate I/II disease compared with the minor severity of illness group.References Notes[ ]
