Natural Med. Cond. ⇒ Natural Nose microbiome {40000641} Record Keys Type:Natural Med. Cond. Parent:[ ] Definition:Natural Nose microbiome Details Initialisation date:[ ] Other Terms:[ ] Meta Information MedDra ID:[ ] MedDra Level:[ ] ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Parkinson’s Disease] - signals from nasal microbiota reach the brain through the olfactory system and affect the nervous system function. - Although 104 different strains of bacteria are present in the nose, only two to ten species make up 90% of an individual’s nasal microbiome [#Parkinson’s Disease] [#Alpha-synuclein] - Chronic nasal dysbiosis induced by local inflammation can significantly enhance neurodegenerative damage of OSNs, which leads to an accumulation of misfolded aSyn. - Misfolded aSyn commonly appears in the olfactory bulb tissue and neuroepithelium samples of PD patients. - Olfactory dysfunction has been observed in the early phase of PD progression. - #Firmicutes and #Proteobacteria are abundantly present in #Children, whereas #Actinobacteria are over-represented in adults. [#Butyric acid] - the presence of butyric-acid-producing bacteria in the nasal microbiome caused alterations in the olfactory functions. - #Haemophilus influenzae, #Moraxella catarrhalis, and #Streptococcus pneumoniae, are also occasionally detected in nasal microbiota.References Notes[ ]
