Disease ⇒ Small intestinal bacterial overgrowth {40000142} Record Keys Type:Disease Parent:[ ] Definition:Small intestinal bacterial overgrowth Details Initialisation date:0000-00-00 Other Terms:SIBO Meta Information MedDra ID:[ ] MedDra Level:[ ] ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] - The most notable intrinsic factors preventing Small intestinal bacterial overgrowth are gastric acid and bile acid (BA) secretion, peristaltic movement, normal gut defense mechanisms, the production of mucin, gut antibacterial peptides, and prevention of bacterial retrograde translocation from the lower gut to the upper gut via the ileocecal valve. - Extrinsic factors preventing Small intestinal bacterial overgrowth include nutrient intake and diet, bacterial and viral infection, medications altering motility (prokinetics), and drugs modulating the gut microbiota, for instance, pre and probiotics, proton pump inhibitors, H2 blockers, and antibiotics. - Based on jejunal aspirate cultures, Escherichia coli, Streptococcus species (spp.), Pseudomonas aeruginosa, Staphylococcus spp., Acinetobacter baumannii, Acinetobacter lwoffii, Enterococcus faecium, Klebsiella pneumoniae, and Enterococcus faecalis were predominantly found in patients with SIBO who suffered altered GI motility. [1.2] [#Parkinson’s Disease] - Bacterial overgrowth of the small intestine (SIBO): 25% of PD patients > inflammation-mediated effect. -SIBO > gastrointestinal dysfunction > increasing intestinal permeability, proinflammatory cytokine activation and, consequently, microglial activation > a deterioration in motor skills and can also affect the absorption of levodopa > PD [1.3] [#Tryptophan] - small intestinal bacterial overgrowth (SIBO), can shift Trp metabolism in the small intestine, driving an increase in locally produced #kynurenineReferences Notes[ ]
