Carnobacterium ⇒ Carnobacterium maltaromaticum {50002726} Record Keys Parent:Carnobacterium Definition:Carnobacterium maltaromaticum Details Initialisation date:[ ] Meta Information Rank: Species Domain:[ ] Zone:[ ] Enzyme:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Colorectal cancer] [#Faecalibacterium prausnitzii] - F. prausnitzii, converts C. maltaromaticum-derived 7-DHC into downstream #Vitamin D metabolites for mediating the anti-CRC effect. [#Colorectal cancer] [#Gender] - C. maltaromaticum was specifically depleted in female patients with CRC. - Oral administration of C. maltaromaticum suppressed intestinal tumorigenesis in two murine CRC models in a female-specific manner. - CRC-suppressing effect of C. maltaromaticum were dependent on estrogen, with SLC3A2 identified as an estrogen-responsive host surface protein for binding to C. maltaromaticum. - female mice expressed higher colonic SLC3A2, and with enough estrogen (mice of adult age), C. maltaromaticum bound to the colonic SLC3A2 via its surface protein, named DD-CPase. [#Colorectal cancer] [#Lipopolysaccharide] - C. maltaromaticum could restore the gut barrier function at the early time points. - The restoration of gut barrier function was associated with increased expression of a number of associated markers, including ZO-1, #Occludin, and E-cadherin in mouse CRC models, enhanced thickness of colonic mucus layer, along with decreased paracellular gap and serum LPS level. - VDR signaling was activated significantly in C. maltaromaticum-treated mice, and the tumor-suppressive effect of C. maltaromaticum was dependent on VDR.References Notes[ ]
