Estradiol {90000623} Record Keys Parent:[ ] Definition:Estradiol Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:Hormon Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Postmenopausal] - estradiol-degrading #Klebsiella aerogenes from the feces of premenopausal females with #Depression > In mice, gavaging with this strain led to estradiol decline and #Depression-like behaviors. - The gene encoding the estradiol-degrading enzyme in K. aerogenes was identified as 3β-hydroxysteroid dehydrogenase (3β-HSD). - The prevalence of K. aerogene and 3β-HSD was higher in premenopausal women with #Depression than in those without #Depression. [#Escherichia coli] - Gavaging mice with 3β-HSD-expressing E. coli decreased their serum estradiol levels, causing #Depression-like behaviors. [#Depression] [#Gender] - Estradiol decline can result in depressive disorders in females [1.2] - testosterone supplementation and reduction of 17 beta-estradiol activated the renin-angiotensin-aldosterone system to increase BP [1.3] [#Alzheimer’s disease] [#Amyloid-beta] - Early stage ovariectomy (OVX) leads to a reduction of plasma estradiol that is correlated with a significant alteration of gut microbiome composition and reduction in Aβ pathology. - supplementation of OVX-treated animals with estradiol restores Aβ burden and influences gut microbiome composition.References Notes[ ]
