Colibactin {60000098} Record Keys Parent:[ ] Definition:Colibactin Queue:[ ] Details Initialisation date:2020-10-12 Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:Cytokine Function:Oncogenesis, Genotoxin Notes: - The genotoxin colibactin is produced by polyketide synthase-positive E. coli and induces DNA double-strand breaks in vitro and in vivo. It increases tumor formation in vitro alone, or in co-colonization with ETBF in FAP patients. (1) - Cloibactin form interstrand cross-links by alkylation of adenine residues on opposing strands of DNA. - Cloibactin is produced in small quantities and is unstable so that cell-to-cell contact is required for genotoxic effects. (2)Shared Reference Notes [1.1] - #Escherichia coli generates and secretes colibactin, which crosslinks eukaryotic DNA, leading to double-strand DNA breaks [1.2] - Colibactin is a genotoxic secondary metabolite produced by certain strains of gut bacteria, such as #Escherichia coli and #Klebsiella pneumoniae. Colibactin can cause DNA damage and promote the development of #Colorectal cancer . [1.3] [#Colorectal cancer] [#Escherichia coli] - Colibactin-producing pks+ E. coli+ promotes CRC development by causing double-stranded DNA breakage and a specific pattern of mutational signature, namely SBS88 and ID18. - early-life exposure to pks+ E. coli+ may influence early-onset tumorigenesis. - Pks+ E. coli+ is a common gut bacteria found in ~31% of healthy #Infants by 1-month post-birth. - prolonged exposure to this bacteria may be necessary to result in DNA damage. - pks+ E. coli+ does not cause a highly immunogenic tumour microenvironment (TME), at least at the time of CRC diagnosis/resection.References Notes (1) [1.4] (2) [1.5]
