Colibactin {60000098}
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| Definition: | Colibactin |
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| Initialisation date: | 2020-10-12 |
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| Specification: | |
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| Structural Type: | [ ] |
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| Functional Type: | Cytokine |
| Function: | Oncogenesis, Genotoxin |
Notes:
- The genotoxin colibactin is produced by polyketide synthase-positive E. coli and induces DNA double-strand breaks in vitro and in vivo. It increases tumor formation in vitro alone, or in co-colonization with ETBF in FAP patients. (1)
- Cloibactin form interstrand cross-links by alkylation of adenine residues on opposing strands of DNA.
- Cloibactin is produced in small quantities and is unstable so that cell-to-cell contact is required for genotoxic effects. (2)
Shared Reference Notes
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References Notes
- (1) [1.1]
- (2) [1.2]