Arachidonic acid {90000209} Record Keys Parent:[ ] Definition:Arachidonic acid Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:Lipid Functional Type:Energy Source Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Amyotrophic lateral sclerosis] - In spinal motor neurons human induced pluripotent stem cell lines > elevated levels of arachidonic acid. - Pharmacological reduction of arachidonic acid levels > reverse ALS-related phenotypes in both human sMNs and in vivo in Drosophila and SOD1G93A mouse models. [1.2] [#Juvenile idiopathic arthritis] - Low levels of arachidonic acid (AA) and #Docosahexaenoic acid (DHA) have been described in the active phase of JIA, with total n-3 polyunsaturated fatty acids (PUFAs) lower in JIA and negatively correlated with inflammation. [1.3] - In the serotonergic synapse pathway, arachidonic acid can relax blood vessels and reduce #HypertensionReferences Notes[ ]
