Constitutive androstane receptor {40000670} Record Keys Type:[ ] Parent:[ ] Definition:Constitutive androstane receptor Details Initialisation date:[ ] Other Terms:[ ] Meta Information MedDra ID:[ ] MedDra Level:[ ] ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Diabetes Type 2, #Metabolic associated fatty liver disease] [#3,3′-Diindolylmethane] - CAR plays a critical role in regulating the breakdown, uptake and removal of foreign substances in the liver, including drugs. - CAR plays a role in diabetes, fatty liver disease and small intestine #Ulcerative Colitis - The diindoles, diindolylmethane (DIM) and #Diindolylethane (DIE) selectively up-regulate bona fide CAR target genes in primary human hepatocytes and mouse liver without causing significant side effects. References Notes[ ]
