Bacteroides fragilis toxin {90000198} Record Keys Parent:[ ] Definition:Bacteroides fragilis toxin Queue:[ ] Details Initialisation date:2021-09-11 Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:Oncogenesis, Genotoxin Notes: [ ]Shared Reference Notes [1.1] [#Cancer] - #Bacteroides fragilis toxin (Bft), can indirectly damage the host DNA by eliciting high levels of reactive oxygen species (ROS) [1.2] [#Pancreatic Cancer] - Enterotoxigenic #Bacteroides fragilis (ETBF) produces #Bacteroides fragilis toxin (BFT), which is associated with acute diarrheal, inflammatory bowel disease, and #Colorectal cancer (CRC). [1.3] [#Bacteroides fragilis, #Bacteroides fragilis group] - BFT expression increased goblet cell number and goblet-cell-associated passage formation. [1.4] [#Bacteroides fragilis] [#E-cadherin] - Specific strains of B. fragilis excrete a toxin known as B. fragilis toxin (BFT), which is a metalloprotease capable of cleaving E-cadherins > increases gut permeability and may lead to leaky gut. References Notes[ ]
