2-methylbutyrylcarnitine {90000735} Record Keys Parent:[ ] Definition:2-methylbutyrylcarnitine Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Thrombotic events] [#Acylcarnitines] [#Antibiotic Therapy] - 2-methylbutyrylcarnitine (2MBC), a branched-chain acylcarnitine, is accumulated in patients with #Covid-19 and in patients with major adverse cardiovascular events (MACEs). - 2MBC enhances platelet hyperreactivity and thrombus formation in mice. - 2MBC binds to integrin α2β1 in platelets, potentiating cytosolic phospholipase A2 (cPLA2) activation and platelet hyperresponsiveness. - Genetic depletion or pharmacological inhibition of integrin α2β1 largely reverses the pro-thrombotic effects of 2MBC. - 2MBC can be generated in a gut-microbiota-dependent manner, whereas the accumulation of plasma 2MBC and its thrombosis-aggravating effect are largely ameliorated following antibiotic-induced microbial depletion. References Notes[ ]
