3-hydroxykynurenine {90000418}
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| Definition: | 3-hydroxykynurenine |
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| Function: | Neurotoxic |
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Shared Reference Notes
- [1.1]
- high levels of 3-HK are associated with several psychiatric disorders. - [#kynurenine] - Kyn can be metabolized either to #kynurenic acid (KYNA), with neuroprotective properties, or to the neurotoxic components #Quinolinic acid (QA) and 3-hydroxykynurenine (3-HK)
- [#Bipolar disorder] [#Quinolinic acid, #kynurenic acid, #kynurenine] - individuals with BD present lower peripheral blood levels of #Tryptophan, Kyn, KYNA, xanthurenic acid (a component derived from 3-HK), KYNA/Kyn and KYNA/QA ratio
References Notes
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