Sphingolipid {90000166}

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Shared Reference Notes

  • [1.1
    - #Food Allergy was uniquely associated with a marked decrease in sphingolipid levels, as well as levels of a number of other lipid metabolites, in the face of normal frequencies of circulating natural killer T cells.
  • [1.2
    - High ceramide levels > associated with insulin resistance, hypercholesterolemia, liver steatosis, and the formation of lipid rafts. - Some classes of #Ceramides in the blood increase the risk for late-onset #Alzheimer’s disease, as they are neurotoxic and induce apoptosis . - #Bacteroidetes phylum can synthesize sphingolipids > human epithelial cells > #Ceramides
  • [1.3] [#Necrotizing enterocolitis
    - #Phospholipids, are important metabolites for intestinal cell integrity and maturation, and disruptions in sphingolipid metabolism impliy in the pathogenesis of preterm necrotising enterocolitis.
  • [1.4] [#Inflamatory bowel disease
    - The ratio between fecal #Lactosyl-N-palmitoyl-sphingosine and #L-urobilin discriminated IBD and non-IBD samples, with the sphingolipid occurring at higher relative abundance in stool from IBD patients.
  • [1.5] [#Ceramides, #Sphingolipids

References Notes

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Common References

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