Sphingolipid {90000166} Record Keys Parent:[ ] Definition:Sphingolipid Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] - #Food Allergy was uniquely associated with a marked decrease in sphingolipid levels, as well as levels of a number of other lipid metabolites, in the face of normal frequencies of circulating natural killer T cells. [1.2] - High ceramide levels > associated with insulin resistance, hypercholesterolemia, liver steatosis, and the formation of lipid rafts. - Some classes of #Ceramides in the blood increase the risk for late-onset #Alzheimer’s disease, as they are neurotoxic and induce apoptosis . - #Bacteroidetes phylum can synthesize sphingolipids > human epithelial cells > #Ceramides [1.3] [#Necrotizing enterocolitis] - #Phospholipids, are important metabolites for intestinal cell integrity and maturation, and disruptions in sphingolipid metabolism impliy in the pathogenesis of preterm necrotising enterocolitis. [1.4] [#Inflamatory bowel disease] - The ratio between fecal #Lactosyl-N-palmitoyl-sphingosine and #L-urobilin discriminated IBD and non-IBD samples, with the sphingolipid occurring at higher relative abundance in stool from IBD patients. [1.5] [#Ceramides, #Sphingolipids] References Notes[ ]
