Symptom ⇒ Neuropathic Pain {40000630} Record Keys Type:Symptom Parent:[ ] Definition:Neuropathic Pain Details Initialisation date:[ ] Other Terms:[ ] Meta Information MedDra ID:[ ] MedDra Level:[ ] ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] - Neuroinflammation is a central factor in neuropathic pain (NP). - pathogen-associated molecular patterns can indirectly increase the excitability of DRG neurons by inducing pro-inflammatory factors (e.g., tumor necrosis factor-α, interluekin-1β, and interluekin-6) and chemokine (e.g., monocyte chemoattractant protein-1) release from immune cells to enhance pain [#Gingerols, #Shogaols] - Administration of #Ginger root extract or its individual bioactive compound (e.g., 6-gingerol, 6-shogaol, 8-shogaol) has also shown to mitigate pain in animals with SNI-induced NP [#Short Chain Fatty Acid] - short-chain fatty acids (SCFA) and bile acids can indirectly decrease the excitability of dorsal root ganglion (DRG) neurons by releasing anti-inflammatory cytokines (i.e., interluekin-4, #IL-4) or neuropeptides (e.g., opioids) from immune cells to inhibit painReferences Notes[ ]
