Desulfohalobiaceae ⇒ Desulfonatronospira {50002739} Record Keys Parent:Desulfohalobiaceae Definition:Desulfonatronospira Details Initialisation date:[ ] Meta Information Rank: Genus Domain: Bacteria Zone:[ ] Enzyme:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Immune checkpoint inhibitor] - #Eudoraea and Desulfonatronospira showed significant increase in patients who benefited from the treatment, suggesting that increasing abundance of these two genera in tumors may improve the outcome of ICB treatment. - #Eudoraea could enhance anti-PD-1 immunotherapy in #Melanoma. - Treatment with #Eudoraea alone or in combination with anti-PD-1 did not result in significant changes in spleen size and body weight. - increases in the percentage of immune cells in the tumor, percentage of CD8+ T cells in the T cells (CD8+/CD3+), and percentage of cytolytic T cells in the CD8+ T cells (GZMB+/CD8+) for the combination of anti-PD-1 and #Eudoraea. - 458 upregulated and 10 downregulated genes in the combination therapy of anti-PD-1 and #Eudoraea vs. anti-PD-1.References Notes[ ]
