Alpha defensins {90000702} Record Keys Parent:[ ] Definition:Alpha defensins Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Akkermansia muciniphila] - In culture and in mice, A. muciniphilia modified IgA1 and converted it into a deglycosylated form associated with #IgA nephropathy. - This process created new antigens that crossed the lining of the intestines and entered the blood, eventually settling into the glomeruli region of the kidneys. - Mice expressing human IgA1 ended up developing IgA_nephropathy after being colonised with A. muciniphila. - Antimicrobial peptides called alpha_defensins suppressed the growth of A. muciniphila in culture, but that these protective effects seemed to be lost in stool samples from patients.References Notes[ ]
