Disease ⇒ IgA nephropathy {40000656} Record Keys Type:Disease Parent:[ ] Definition:IgA nephropathy Details Initialisation date:[ ] Other Terms:[ ] Meta Information MedDra ID:[ ] MedDra Level:[ ] ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Akkermansia muciniphila] [#Alpha defensins] - In culture and in mice, A. muciniphilia modified IgA1 and converted it into a deglycosylated form associated with IgA nephropathy. - This process created new antigens that crossed the lining of the intestines and entered the blood, eventually settling into the glomeruli region of the kidneys. - Mice expressing human IgA1 ended up developing IgA_nephropathy after being colonised with A. muciniphila. - Antimicrobial peptides called alpha_defensins suppressed the growth of A. muciniphila in culture, but that these protective effects seemed to be lost in stool samples from patients.References Notes[ ]
