Indolimines {90000358} Record Keys Parent:[ ] Definition:Indolimines Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:Cytokine Function:Oncogenesis, Genotoxin Notes: [ ]Shared Reference Notes [1.1] [#Colorectal cancer, #Inflamatory bowel disease] - Morganella morganii is enriched in the gut microbiota of both IBD and CRC patients. - Morganella morganii-derived small-molecule genotoxins—termed the Indolimines—that elicited DNA damage in cell-based and cell-free assays. - In a mouse model of colon cancer, M. morganii exacerbated tumor burden, but a mutant form of the bacteria unable to produce indolimine did not.References Notes[ ]
