Lipopolysaccharide ⇒ BF-LPS {90000335} Record Keys Parent:Lipopolysaccharide Definition:BF-LPS Queue:[ ] Details Initialisation date:2022-08-10 Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:Neurotoxic Notes: [ ]Shared Reference Notes [1.1] [#Alzheimer’s disease] [#Lipopolysaccharide] - #Bacteroides fragilis in the human gastrointestinal (GI) tract generates > neurotoxin BF-LPS > BF-LPS leaks out of the GI tract, crosses the blood brain barrier via the circulatory system, and accesses brain compartments > inreases inflammation in brain cells and inhibits neuron-specific neurofilament light (NF-L,) a protein that supports cell integrity > deficiency of NF-L > consequent atrophy of the neuronal cytoskeleton and the disruption of synaptic organization.References Notes[ ]
