Disease ⇒ Aortic aneurysm {40000665} Record Keys Type:Disease Parent:[ ] Definition:Aortic aneurysm Details Initialisation date:[ ] Other Terms:[ ] Meta Information MedDra ID:[ ] MedDra Level:[ ] ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] - Elevated #TMAO was associated with increased abdominal aortic aneurysm (AAA) incidence and growth in both patient cohorts studied. - Dietary #Choline supplementation augmented plasma #TMAO and aortic diameter in both mouse models of AAA, which was suppressed with poorly absorbed oral broad-spectrum antibiotics. - Treatment with fluoromethylcholine ablated #TMAO production, attenuated #Choline-augmented aneurysm initiation, and halted progression of an established aneurysm model.References Notes[ ]
