Disease ⇒ Glioblastoma {40000155} Record Keys Type:Disease Parent:[ ] Definition:Glioblastoma Details Initialisation date:2021-06-16 Other Terms:[ ] Meta Information MedDra ID:[ ] MedDra Level:[ ] ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Keto diet] - This is the first report of confirmed IDH1-mutant GBM treated with KMT and surgical debulking without chemo- or radiotherapy. The long-term survival of this patient, now at 80 months, could be due in part to a therapeutic metabolic synergy between KMT and the IDH1 mutation that simultaneously target the glycolysis and glutaminolysis pathways that are essential for GBM growth. [1.2] [#Brain Tumor] - enriched (Verrucomicrobia and Akkermansia) and depleted taxa (Firmicutes and subsequent Firmicutes/Bacteroides ratio) in both mouse glioma models and glioma patients [1.3] - QUIN was also shown to enhance glioblastoma cell survival when in excess. - The enhanced cell survival may be due to the excess QUIN increasing the availability of NAD+ when catabolised. This NAD+ is then utilised in DNA repair, essentially reducing the apoptosis that was triggered by chemotherapeutic drugs-References Notes[ ]
