Chlamydia pneumoniae {50002152}

Shared Reference Notes

• [1.1] 
  - C. pneumoniae is unique among several microbes that have been associated with arterial disease in having been demonstrated with frequency in atherosclerotic lesions but not in normal arterial tissue. - The organism was found not only in coronary arteries but also in carotid, aortic, femoral and popliteal arteries.
• [1.2] [#Alzheimer’s disease] 
  - Among different types of microbes, #Human immunodeficiency virus-1 (HIV-1), #Herpes simplex virus-1 (HSV-1), Chlamydia pneumonia, #Spirochetes and #Candida albicans are frequently detected in the brain of AD patients. - #Amyloid-beta protein has demonstrated to exhibit antimicrobial properties upon encountering these pathogens.
• [1.3] 
  - #Alzheimer’s disease brains tissue > presence of #HSV1, #Borrelia burgdorferi, and Chlamydia pneumoniae in AD brains.
• [1.4] [#Amyloid-beta] 
  - Chlamydia pneumoniae can infect the olfactory and trigeminal nerves, olfactory bulb and brain within 72 h in mice. - Chlamydia pneumoniae infection also resulted in dysregulation of key pathways involved in #Alzheimer’s disease pathogenesis at 7 and 28 days after inoculation. - Amyloid beta accumulations were also detected adjacent to the Chlamydia pneumoniae inclusions in the olfactory system. - Injury to the nasal epithelium resulted in increased peripheral nerve and olfactory bulb infection, but did not alter general CNS infection.

References Notes