Microbiome & Chronic Diseases

Evidence Based Medicine

Lachnospiraceae {10000240}

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- Short chain fatty acid producer

Shared Notes

  • [1.97
    - Blautia, Coprococcus, Dorea, Lachnospira, Oribacterium, Roseburia, and L-Ruminococcus (Ruminococcus genus assigned to the Lachnospiraceae family) are the main genera that have been detected in the human intestine by metagenomics analyses. - All members of Lachnospiraceae are anaerobic, fermentative, and chemoorganotrophic, and some display strong hydrolyzing activities, through the activity of pectin methyl-esterase, pectate lyase, xylanase, α-L-arabinofuranosidase, β-xylosidase α- and β-galactosidase, α- and β-glucosidase, N-acetyl-β-glucosaminidase, or α-amylase.
    - Lachnospiraceae are present in early infants, found even in the meconium.
    - increases in Lachnospiraceae abundances are associated with aging.
    - Lachnospiraceae abundance also increases in the intestinal lumen of subjects with different diseases, although the taxa of this family have repeatedly shown their ability to produce beneficial metabolites for the host.
  • [1.98
    - Different genera of Lachnospiraceae were negatively associated with body fat, LDL and total cholesterol.
    - Lachnospiraceae is associated with lipid cardiovascular risk factors.
  • [1.99
    - The Lachnospiraceae count was lower among infants with higher maternal consumption of dietary fiber
  • - The abundance of Lachnospiraceae was inversely affected by dietary fiber, magnesium, and potassium.
  • [1.100
    - Decreased Lachnospiraceae > reduction in anti-inflammatory and neuroprotective metabolite in PD
    Increased Bacteroides and Verrucomicrobia > Metabolites correlated positively with the frequency of the proinflammatory cytokines TNF-α and IFN-γ

Common References