MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

Porphyromonas gingivalis ⇒ Porphyromonas {10000232}

Record Keys


Organism:
Porphyromonas gingivalis
Class:

Details


Initialisation date:
2020-06-01

Links


Meta Information


Taxonomy:
Species
Domain:
Bacteria
Zone:
Oral cavity
Enzyme:[  ]
Function:[  ]

Notes


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Shared Notes


  • [1.22
    - Anti‐Porphyromonas gingivalis (Pg) antibody titers positively correlated with intramuscular adipose tissue content (IMAC), fasting blood glucose, and HOMA‐IR in metabolic syndrome patients.
    - Pg administration altered the gut microbiome, particularly by decreasing the abundance of genus Turicibacter.
  • [1.23
    - The Gram-negative bacterium Porphyromonas gingivalis is a secondary colonizer of the oral biofilm and is involved in the onset and progression of periodontitis.
  • [1.24
    - Even a single administration of oral P. gingivalis can increase the prevalence of Bacteroidetes while decreasing the abundance of Firmicutes
  • - The presence of P. gingivalis in the GI microbiota has been linked with a milieu of inflammatory/autoimmune diseases associated with GI dysbiosis including RA and NAFLD
  • [1.21
    - Increased serum levels of the antibodies IgM rheumatoid factor (IgM-RF) and antibodies against citrullinated proteins (ACPA) in healthy individuals imply an elevated risk of developing RA
    - The possible role of Porphyromonas gingivalis in the immunopathogenesis of RA has been of particular interest due to its capacity to generate citrullinated proteins.

Common References