MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

Colibactin {60000098}

Record Keys


Biotic:
Colibactin
Parent:[  ]
Queue:[  ]

Details


Authoring date:
2020-10-12
Specification:
[  ]
Source:
[  ]

Meta Information


Structural Type:[  ]
Functional Type:
Cytokine
Function:
Oncogenesis, Genotoxin

Notes


- The genotoxin colibactin is produced by polyketide synthase-positive E. coli and induces DNA double-strand breaks in vitro and in vivo. It increases tumor formation in vitro alone, or in co-colonization with ETBF in FAP patients. (1)

- Cloibactin form interstrand cross-links by alkylation of adenine residues on opposing strands of DNA.
- Cloibactin is produced in small quantities and is unstable so that cell-to-cell contact is required for genotoxic effects. (2)