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- IL-17A is expressed in mucosal cells and contributes to intestinal homeostasis but might promote inflammation in excess.
- IL-17A is mainly produced by Th17 cells. It can also be produced by γδ T cells, natural killer (NK) T cells, macrophages, neutrophils, and eosinophils, but their regulation of IL-17A expression is different.
- IL-17 molecules from the gut can influence autoimmune diseases in the central nervous system by regulating the gut microbiota rather than directly triggering brain inflammation
- [1.1] IL-17 controls central nervous system autoimmunity through the intestinal microbiome  [Research]  [Science Immunology] [Journal]