Microbiome & Chronic Diseases

Evidence Based Medicine

Human milk oligosaccharides {60000075}

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Human milk oligosaccharides
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- Human milk oligosaccharides (HMO) are complex carbohydrates abundant in breast milk. Intriguingly, these molecules do not provide energy to the infant. Instead, these oligosaccharides are key to guide and support the assembly of a healthy gut microbiome in the infant, dominated by beneficial gut microbes such as Bifidobacterium. New analytical methods for glycan analysis, and next-generation sequencing of microbial communities, have been instrumental in advancing our understanding of the positive role of breast milk oligosaccharides on the gut microbiome, and the genomics and molecular strategies of Bifidobacterium to utilize these oligosaccharides. (1)

Shared Notes

  • [1.1
    - Low gut bacterial diversity in breastfeeding infants is thought to be a result of breastmilk oligosaccharides which serve as substrates for a limited number of gut microbes
  • [1.2
    - Patients had a significant improvement from baseline to 12 weeks in total percentage of bowel movements.
    - Improvement was similar across IBS subtypes. Symptoms improved most in the first 4 weeks of intervention.
    - The most common side effects were mild gastrointestinal symptoms such as flatulence, abdominal pain and discomfort, and distension.

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