N-acyl amides {90000676} Record Keys Parent:[ ] Definition:N-acyl amides Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] - The microbiome creates N-acyl amides (NAAs) that closely mimic the function of endogenously produced signaling molecules, particularly endocannabinoids. - The microbiome is capable of producing 6 families of N-acyl amides: N-acyl glycine, N-acyloxyacyl lysine, N-acyloxyacyl glutamine, N-acyl lysine/ornithine, N-acyl alanine, and N-acyl serinol. - These NAA mimics can serve as agonists or antagonists of G-protein-coupled receptors (GPCR). - Sample type can impact the NAAs detected in a study. - the majority of detected N-acyl homoserine molecules are present in serum, cecal content, and liver samples, some N-acyl homoserines are detected exclusively in one sample type, such as 3OH-C10-HSL only being detected in serum and C12-HSL only being detected in liver and cecal content. - it may be beneficial to collect at least one biofluid and one tissue sample based on the NAA of interest.References Notes[ ]
