Aerugine {90000653} Record Keys Parent:[ ] Definition:Aerugine Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:Neurotoxic Notes: [ ]Shared Reference Notes [1.1] [#Parkinson’s Disease] - aerugine (C10H11NO2S; 2-[4-(hydroxymethyl)-4,5-dihydro-1,3-thiazol-2-yl]#Phenol) [2-hydroxyphenyl-thiazoline] is a product of a wide-spread biosynthetic cluster also found in the human microbiome and in several pathogens. - Aerugine triggered half-maximal dopaminergic neurotoxicity at 3–4 µM. - It was less toxic for other neurons (10–20 µM), and non-toxic (at <100 µM) for common human cell lines.References Notes[ ]
