Neprilysin {90000618} Record Keys Parent:[ ] Definition:Neprilysin Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Alzheimer’s disease] [#Amyloid-beta] - #Tryptophan metabolites have been shown to regulate the cerebral activity of neprilysin, a metalloproteinase that controls the degradation and clearance of Aβ peptides in the brain. [1.2] [#Alzheimer’s disease] [#Porphyromonas gingivalis] [#Lipopolysaccharide] - intraperitoneally injection of P. gingivalis LPS led to a reduction in the expression of neprilysin in the hippocampus > lower levels of neprilysin have been associated with increased Aβ accumulation in ADReferences Notes[ ]
