DOPA decarboxylase {90000611} Record Keys Parent:[ ] Definition:DOPA decarboxylase Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:Anti-atherosclerosis, Anti-angiogenesis Notes: [ ]Shared Reference Notes [1.1] [#Parkinson’s Disease] - cerebrospinal fluid levels of DOPA decarboxylase (DDC) (also known as aromatic L-amino acid decarboxylase) can accurately identify patients with Lewy body disease (LBD) and are associated with worse cognitive performance. - DDC can detect preclinical LBD stages in clinically unimpaired individuals with a positive seed amplification α-synuclein assay and that this biomarker could predict progression to clinical LBD over a 3-year period in preclinical cases - DDC levels were also increased in atypical Parkinsonian disorders but not in non-Parkinsonian neurodegenerative disorders.References Notes[ ]
