MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

Metformin {60000057}

Record Keys


Biotic:
Metformin
Class:[  ]
Queue:[  ]

Details


Initialisation date:
2020-09-21
Specification:

N,N-dimethylbiguanide

Source:
[  ]

Links


Meta Information


Structural Type:[  ]
Functional Type:[  ]
Function:[  ]

Notes


- Lactate uptake by the liver is diminished with metformin use because lactate is a substrate for hepatic gluconeogenesis, a process that metformin inhibits.
- Metformin has been suggested as increasing production of lactate in the large intestine.
- Epidemiological studies first recognized a relationship with metformin use in T2DM patients and reduced colorectal cancer (CRC) risk. (2)

- metformin treatment significantly increase Escherichia coli and lowers Intestinibacter abundance.
- This effect is thought to be mediated by metformin’s effect on short-chain fatty acid (butyrate)-producing bacteria and the abundance of Akkermansia muciniphila, as well as through common biological pathways and genes encoded in different metformin-affected bacteria. (3)

-bcat-1 knockdown increases mitochondrial respiration and induces oxidative damage in neurons through mammalian target of rapamycin-independent mechanisms. Increased mitochondrial respiration, or "mitochondrial hyperactivity," is required for bcat-1(RNAi) neurotoxicity.
-Post-disease-onset administration of the type 2 diabetes medication metformin reduces mitochondrial respiration to control levels and significantly improves both motor function and neuronal viability.(4)

Shared Notes


  • [1.1
    - metformin treatment, shifts a depletion of butyrate-producing taxa in T2D patient. These in turn cause functional microbiome shifts, in part alleviated by metformin-induced changes.
  • [1.2
    - The commonly used diabetes treatment Metformin increase Akkermansia spp. abundance, and to significantly improve glucose metabolism in high-fat diet fed mice while also increasing the number of mucin-producing goblet cells.
  • [1.3
    - there is a negative association between specific species such as B. adolescentis, B. bifidum, B. pseudocatenulatum, B. longum, B. dentium and disease in patients treated with metformin or after undergoing gastric bypass surgery

Common References