MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

Tryptamine {60000056}

Record Keys


Biotic:
Tryptamine
Class:[  ]
Queue:[  ]

Details


Initialisation date:
2020-09-06
Specification:

- Tryptamine is a monoamine metabolite produced from tryptophan by gut bacteria

Source:
[  ]

Meta Information


Structural Type:[  ]
Functional Type:[  ]
Function:[  ]

Notes


[  ]

Shared Notes


  • [1.1
    - Tryptamine is found abundantly in human and rodent stool samples.
    - The role of tryptamine in the GI tract is facilitated by the 5-HT4 receptor that is only found in colonic epithelium.
    - Tryptamine produced increase movement across the colonic epithelium as well as fluid secretions in colonoids for proper intestinal secretion.
    - Improved GI motility was seen in GF mice that were colonized with tryptamine-producing engineered Bacteroides thetaiotaomicron microbes.
  • [1.2
    - Clostridium sporogenes is able to decarboxylate Trp leading to the production of the neurotransmitter tryptamine.

Common References