- Tryptamine is a monoamine metabolite produced from tryptophan by gut bacteria
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- Tryptamine is found abundantly in human and rodent stool samples.
- The role of tryptamine in the GI tract is facilitated by the 5-HT4 receptor that is only found in colonic epithelium.
- Tryptamine produced increase movement across the colonic epithelium as well as fluid secretions in colonoids for proper intestinal secretion.
- Improved GI motility was seen in GF mice that were colonized with tryptamine-producing engineered Bacteroides thetaiotaomicron microbes.
- Clostridium sporogenes is able to decarboxylate Trp leading to the production of the neurotransmitter tryptamine.
- [1.1] Gut Microbial Dysbiosis in the Pathogenesis of Gastrointestinal Dysmotility and Metabolic Disorders  [Review]  [Neurogastroenterology & Motility] [Journal]
- [1.2] Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease  [Review]  [Cell Host & Microbe] [Journal]