Allura Red AC {90000496} Record Keys Parent:[ ] Definition:Allura Red AC Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: Allura Red AC (AR) is a highly common synthetic colorant.Shared Reference Notes [1.1] - chronic exposure of AR at a dose found in commonly consumed dietary products exacerbates experimental models of #Colitis in mice. - chronic exposure to AR induces mild #Colitis, which is associated with elevated colonic serotonin (5-hydroxytryptamine; 5-HT) levels and impairment of the epithelial barrier function via myosin light chain kinase (MLCK). - intermittent exposure to AR in mice for 12 weeks, does not influence susceptibility to #Colitis. - exposure to AR during early life primes mice to heightened susceptibility to #Colitis. - Cecal transfer of the perturbed gut microbiota by AR exposure worsens #Colitis severity in the recipient germ-free (GF) mice. - chronic AR exposure elevates colonic 5-HT levels in naïve GF mice. References Notes[ ]
