MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

Propionate ⇒ Short Chain Fatty Acid {60000046}

Record Keys


Biotic:
Propionate
Class:
Queue:[  ]

Details


Initialisation date:
2020-09-17
Specification:
[  ]
Source:
[  ]

Links


Meta Information


Structural Type:
Fatty acid
Functional Type:[  ]
Function:
Pro-inflammatory

Notes


- Propionate induce glycogenolysis and hyperglycaemia by hindering the effects of insulin.
- Propionate may cause gut lumen inflammation.
- Metformin intake may increase Propionate.

Shared Notes


  • [1.3
    - Propionate interacts with a type of immune system cell mononuclear phagocytes that are also found in the lining of the gut which cascade sets of inflammation.
    - Propionate interacts with a type of immune system cell called mononuclear phagocytes that are also found in the lining of the gut and causes inflammation.
  • [1.6
    - Propionate induce glycogenolysis and hyperglycaemia via the upregulation of glucagon and fatty acid-binding protein 4 (FABP4), thereby hindering the effects of insulin.
  • [1.7
    - High doses of propionate, in young rats, induced a neuroinflammatory response and behavioral alterations.
  • [1.8
    - propionate is restricted to certain microorganisms belonging to the phylum Firmicutes or Akkermansia muciniphilla
  • [1.1
    - The abundance of Akkermansia muciniphila, as a key player of propionate production, is associated with the richness of the gut microbiota in patients with BC
  • [1.9
    - Propionate was shown to stimulate PYY and GLP-1 release thereby reducing energy intake.
  • - There is an antihypertensive effect of propionate treatment in mice.
  • [1.11
    - Increases in propionate with increases in leptin, LDL cholesterol, and blood pressure.

Common References