Brain-derived tau {90000362}

Notes:

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[1.1]
- Brain-derived tau is a new blood-based biomarker that outperforms plasma total-tau and, unlike neurofilament light, shows specificity to #Alzheimer’s disease-type neurodegeneration.
[1.2] [#Alzheimer’s disease] [#Short Chain Fatty Acid] [#ApoE4 allele]
- #Amyloid-beta is a necessary factor in AD pathogenesis, its accumulation in and of itself is insufficient for neurodegeneration and cognitive decline. - pathological tau accumulation is closely linked with neurodegeneration and cognitive decline in AD and primary tauopathies. - apolipoprotein E (ApoE) isoforms, which strongly influence AD risk and regulate tau-mediated neurodegeneration, differentially affect the gut microbiota. - microbially produced short-chain fatty acids (SCFAs) are mediators of the neuroinflammation-neurodegeneration axis. - Supplementation of SCFAs to GF TE4 mice resulted in more reactive glial morphologies and gene expression as well as increased p-tau pathology.
[1.3] [#Alzheimer’s disease] [#Amyloid-beta]
- adding #Cinnamon or cinnamaldehyde to a cell medium can reduce tau aggregation, Amyloid β and increase cell viability. - #Cinnamon might be useful for preventing and reducing cognitive function impairment.

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