Fibroblast Growth Factor-2 {90000357} Record Keys Parent:[ ] Definition:Fibroblast Growth Factor-2 Queue:[ ] Details Initialisation date:[ ] Specification: PGF-2Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] - #Candida albicans, a common agent of candidiasis, induces Fibroblast Growth Factor-2 (FGF-2) secretion in vitro and angiogenesis in brains and kidneys during systemic infections. - #Candida albicans hyphae (and not yeast cells) increase the FGF-2 response in human endothelial cells. #Candidalysin, a toxin secreted exclusively by C. albicans in the hyphal state, is required to induce this response. - in the systemic #Candida albicans infection model, mice treated with FGF-2 exhibit significantly higher mortality rates when compared to untreated mice not given the angiogenic growth factor.References Notes[ ]
