Fibroblast Growth Factor-2 {90000357}
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Definition: | Fibroblast Growth Factor-2 |
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PGF-2 | |
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Shared Reference Notes
- [1.1]
- #Candida albicans, a common agent of candidiasis, induces Fibroblast Growth Factor-2 (FGF-2) secretion in vitro and angiogenesis in brains and kidneys during systemic infections. - #Candida albicans hyphae (and not yeast cells) increase the FGF-2 response in human endothelial cells. #Candidalysin, a toxin secreted exclusively by C. albicans in the hyphal state, is required to induce this response. - in the systemic #Candida albicans infection model, mice treated with FGF-2 exhibit significantly higher mortality rates when compared to untreated mice not given the angiogenic growth factor.
References Notes
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