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Shared Reference Notes
- In 214 humans, they found the average blood levels of delta-valerobetaine was 40 percent higher for people with a BMI greater than 30 compared to those with lower BMIs. - delta-valerobetaine contributes to #Obesity and hepatic steatosis by modulating mitochondrial fatty acid oxidation and increasing lipid storage in the adipose tissue and liver.
- delta-valerobetaine production by the gut microbiome reduces cellular carnitine and mitochondrial long-chain acyl-coenzyme A (acyl-CoA); consequently, this obesogenic metabolite prevents mitochondrial fatty acid oxidation and leads to diet-dependent #Obesity.