Citrullinated Proteins {90000167} Record Keys Parent:[ ] Definition:Citrullinated Proteins Queue:[ ] Details Initialisation date:2021-05-12 Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Rheumatoid Arthritis] - Increased serum levels of the antibodies IgM rheumatoid factor (IgM-RF) and antibodies against citrullinated proteins (ACPA) in healthy individuals imply an elevated risk of developing RA - The possible role of #Porphyromonas gingivalis in the immunopathogenesis of RA has been of particular interest due to its capacity to generate citrullinated proteins. [1.2] [#Gingipains] - #Porphyromonas gingivalis is a major pathogenic bacterium involved in the pathogenesis of periodontitis. Citrullination has been reported as the underlying mechanism of the pathogenesis, which relies on the interplay between two virulence factors of the bacterium, namely gingipain R and the bacterial peptidyl arginine deiminase. - Gingipain R cleaves host proteins to expose the C-terminal arginines for peptidyl arginine deiminase to citrullinate and generate Citrullinated Proteins. - Citrullinating proteins present in the host synovial tissues, atherosclerotic plaques and neurons. - both virulence factors are the key factors that trigger distal effects mediated by citrullination, leading to the development of some non-communicable diseases, such as #Rheumatoid Arthritis, #Atherosclerosis, and #Alzheimer’s disease.References Notes[ ]
