Microbiome & Chronic Diseases

Evidence Based Medicine
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p-cresol {90000126}

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Shared Reference Notes

  • [1.1
    - Bacterial fermentation metabolite of tyrosine - Induction of inflammatory reactions and renal and cardiovascular impairment
  • [1.2] [#Autism
    - The microbial metabolite p-Cresol induces selectively ASD core behavioral symptoms in mice. - Social behavior deficits induced by p-Cresol are dependant on changes in microbiota composition.
  • [1.3
    - p-cresol derivatives and the tryptophan breakdown product #Indolepropionate, associated with the gut microbiome.
  • [1.4] [#Autism
  • [1.5
    - #TMAO is the hepatic oxidation product of the microbial trimethylamine (#TMA). - dietary supplementation with #TMAO was shown to promote atherogenesis and development of #Atherosclerosis in mice. - #TMAO levels associate with an increased risk of adverse cardiovascular events. - Carotid #Atherosclerosis was demonstrated to be associated with gut microbial metabolites (especially #TMAO and p-cresol sulfate) in >3,000 patients, which could serve as an independent predictor of the disease.
  • [#Diabetes Type 2] - p-cresol was shown to have the potential to induce diabetes, with mice given p-cresol sulfate for four consecutive weeks showing an insulin-resistant phenotype.
  • [1.6
    - Free #Phenol and p-cresol, most notably produced by Clostridium dificile, are the metabolic products of aromatic amino acids and are the biomarkers of a disturbed gut.

References Notes

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