O-Glycans {90000114} Record Keys Parent:[ ] Definition:O-Glycans Queue:[ ] Details Initialisation date:2020-11-05 Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:Anti-inflammatory Notes: - Colon mucus consists of two distinct O-glycosylated entities of Muc2: a major form produced by the proximal colon, which encapsulates the fecal material including the microbiota, and a minor form derived from the distal colon, which adheres to the major form. The microbiota directs its own encapsulation by inducing Muc2 production from proximal colon goblet cells. In turn, O-glycans on proximal colon-derived Muc2 modulate the structure and function of the microbiota as well as transcription in the colon mucosa.Shared Reference Notes [1.1] [#Candida albicans] - Mucus, specifically mucin O-glycans, suppresses adhesion and filamentation by c. albicans [1.2] - #Akkermansia muciniphila (A. muciniphila) and #Bacteroides thetaiotaomicron (B. theta), have glycoproteases that can degrade the protein core of the mucin domains with shortened O-glycans, but it remains unclear if any of these proteases can cleave intact MUC2. - A major component of mucus is MUC2, a glycoprotein that is extensively decorated, especially with O-glycans. - Mucins are decorated with complex O-glycans that protect this glycoprotein from being easily degraded. - pathogens can be described as true mucin degraders due their ability to break down the mucin polymeric network causing the collapse of the mucus structure to allow bacterial tissue invasion. - commensal bacteria have evolved to utilize mucins by degrading O-glycans without disrupting the inner mucus layer barrier. [1.3] - Core 3-derived O-glycans play an important role in the protective functions of mucus in the proximal colon where they are more highly expressedReferences Notes (1) [1.4]
