O-Glycans {90000114}

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- Colon mucus consists of two distinct O-glycosylated entities of Muc2: a major form produced by the proximal colon, which encapsulates the fecal material including the microbiota, and a minor form derived from the distal colon, which adheres to the major form. The microbiota directs its own encapsulation by inducing Muc2 production from proximal colon goblet cells. In turn, O-glycans on proximal colon-derived Muc2 modulate the structure and function of the microbiota as well as transcription in the colon mucosa.

Shared Reference Notes

  • [1.1] [#Candida albicans
    - Mucus, specifically mucin O-glycans, suppresses adhesion and filamentation by c. albicans
  • [1.2
    - #Akkermansia muciniphila (A. muciniphila) and #Bacteroides thetaiotaomicron (B. theta), have glycoproteases that can degrade the protein core of the mucin domains with shortened O-glycans, but it remains unclear if any of these proteases can cleave intact MUC2.
  • - A major component of mucus is MUC2, a glycoprotein that is extensively decorated, especially with O-glycans. - Mucins are decorated with complex O-glycans that protect this glycoprotein from being easily degraded. - pathogens can be described as true mucin degraders due their ability to break down the mucin polymeric network causing the collapse of the mucus structure to allow bacterial tissue invasion. - commensal bacteria have evolved to utilize mucins by degrading O-glycans without disrupting the inner mucus layer barrier.
  • [1.3
    - Core 3-derived O-glycans play an important role in the protective functions of mucus in the proximal colon where they are more highly expressed

References Notes

  • (1) [1.4

Common References

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