MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

O-Glycans {90000114}

Record Keys


Biotic:
O-Glycans
Parent:[  ]
Queue:[  ]

Details


Authoring date:
2020-11-05
Specification:
[  ]
Source:
[  ]

Meta Information


Structural Type:[  ]
Functional Type:[  ]
Function:
Anti-inflammatory

Notes


- Colon mucus consists of two distinct O-glycosylated entities of Muc2: a major form produced by the proximal colon, which encapsulates the fecal material including the microbiota, and a minor form derived from the distal colon, which adheres to the major form. The microbiota directs its own encapsulation by inducing Muc2 production from proximal colon goblet cells. In turn, O-glycans on proximal colon-derived Muc2 modulate the structure and function of the microbiota as well as transcription in the colon mucosa.