MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

Lipopolysaccharide [LPS, endotoxins] {60000101}

Record Keys


Biotic:
Lipopolysaccharide
Parent:[  ]
Queue:
LPS, endotoxins

Details


Authoring date:
2020-10-14
Specification:
[  ]
Source:

- Outer membrane of Gram-negative bacteria.

Links


Meta Information


Structural Type:
Lipopolysaccharid
Functional Type:[  ]
Function:
Pro-inflammatory, Endotoxin

Notes


[  ]

Shared Notes


  • [1.1
    - Members of the Enterobacteriaceae family have a proinflammatory lipopolysaccharide (LPS) in the outer membrane and can exacerbate inflammation. A high relative abundance of Enterobacteriaceae is reported in inflammatory bowel diseases, in metabolic disorders like type 2 diabetes, and in immune diseases like cancers.
  • [1.2
    - A study performed in Finnish children found a higher abundance of Bacteriodetes dorei prior to auto-immunity and T1D development.
    -The Bacteriodetes phyla produce lipopolysaccharide (LPS), a potent activator of the innate immune system, that in turn increases the auto-immune response in T1D in NOD mice

Common References