Exposure to Glyphosate {51111164}
| Factor: | Exposure to Glyphosate |
|---|---|
| Queue: | [ ] |
| Authoring date: | 2020-12-07 |
|---|---|
| Specification: | |
Roundup 3 | |
| Type: | Antibacterial, Environment |
|---|---|
| Host: | Human , Mouse |
| Zone: | [ ] |
Notes
[ ]
Shared Notes
- [1.1]
- High-dose glyphosate exposure causes higher levels of pro-inflammatory cytokines including IL-1β, IL-6 and TNF-α in addition to increased transcription of mitogen-activated protein (MAP) kinase and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) within the small intestine.
- Subspecies of the Rothia genus have been identified as playing a critical role in the degradation of gluten within the mouth and upper gastrointestinal tract.
- Gluten proteins are difficult to digest by mammalian proteolytic enzymes and recent studies have highlighted microorganism derived enzymes which aid in breaking down these proteins.
- Rothia spp., contain not only the enzymes necessary for protein degradation but also have enzymes that target the immunogenic epitopes that play a crucial role in celiac disease.
- Exposure to Roundup 3Plus® during pregnancy significantly increased the abundance of Turicibacter spp which, in combination with Clostridiaceae, plays a critical role in the modulation of gut-derived serotonin
Common References
- [1.1] Separating the Empirical Wheat From the Pseudoscientific Chaff: A Critical Review of the Literature Surrounding Glyphosate, Dysbiosis and Wheat-Sensitivity [2020] [Review] [80001476] [Frontiers in Microbiology]