MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

Sugar intake {51111159}

Record Keys


Factor:
Sugar intake
Queue:[  ]

Details


Initialisation date:
2020-11-02
Specification:
[  ]

Meta Information


Type:
Diet, Habit
Host:
Human
Mouse
Zone:
Gut Lumen
, Faeces

Notes


[  ]

Shared Notes


  • [1.1
    - The abundance of the mucus-degrading bacteria Akkermansia muciniphila and Bacteroides fragilis was increased.
    - Bacteria-derived mucolytic enzymes were enriched leading to erosion of the colonic mucus layer of sugar-fed mice.
    - Sugar-induced exacerbation of colitis was not observed when mice were treated with antibiotics or maintained in a germ-free environment, suggesting that altered microbiota played a critical role in sugar-induced colitis pathogenesis.

  • [1.3
    - A sugar-rich diet favors the increase of Akkermansia muciniphila, a mucolytic bacterium. The mucus layer separates luminal bacteria from intestinal epithelium: A thinner mucus layer allows bacteria to come in contact with the epithelial cells, eliciting an inflammatory response.
  • - A sugar-rich diet increases the percentage of pro-inflammatory Sutterellaceae and Marinilabiliaceae, which induce bowel inflammation, and reduce bacteria with anti-inflammatory properties like Lachnospiraceae and Lactobacillaceae, able to produce the short-chain fatty acid (SCFA) butyrate, the main anergy source of enterocytes.

Common References